Games like S.E.M.I. – Side Effects May Include...

If S.E.M.I. – Side Effects May Include... left you wanting something funny and colorful, you have options. These games are a good place to start. Plenty here let you team up if you like.

SIDE EFFECTS
A turn-based pill roulette for up to four patients, solo or online. Each round a metal box spills out pills: some help, some hurt, some kill instantly. Manage your resistance, grab experimental items to tilt the odds, and outlive everyone else at the table. Only one of you leaves the trial.
Funny, Chaotic, Surreal
83% of 897 Steam reviews are positivePlayers online now: 9$4.99
SOS OPS!
A co-op chaos game about saving a city, badly. Up to four of you play emergency responders whose fire hoses, rescue cats and teammates all obey wobbly physics, so every mission turns into shouting, falling over and laughing. There are fast story missions, PvP arenas, and no tutorial to slow you down.
Also in Co-op · Funny, Colorful, Chaotic
81% of 5,661 Steam reviews are positivePlayers online now: 99$0.49
Shift Happens
Two jello creatures, one tragic accident, and the ability to swap size at will. Shift Happens is a co-op puzzle platformer built for two: shift your mass, throw each other across gaps and argue over coins through four colorful worlds. Playable solo, best on a couch with a friend.
Also in Co-op · Funny, Colorful, Chaotic
78% of 3,310 Steam reviews are positivePlayers online now: 19$15.99
Climb The Backrooms
Play solo for a truly tense run, or bring up to three friends online and watch the chaos and the jokes take over.
Also in Co-op · Funny, Chaotic, Surreal
81% of 1,033 Steam reviews are positive$4.99
Friendly Steps
You had a fun night out, now you have to walk home. The catch: you steer each leg on its own, while roped to up to three friends. Friendly Steps is a hard, funny co-op physics walk through bridges, stairs, parks and bad shortcuts.
Also in Co-op · Funny, Colorful, Chaotic
64% of 260 Steam reviews are positivePlayers online now: 1$9.99
Struggling
Struggling is a physics-based co-op platformer with a twisted spin on teamwork. Control the arms of a squishy abomination and lead it through a deranged world.
Also in Co-op · Funny, Colorful, Chaotic
93% of 398 Steam reviews are positive$14.99
Healing Spree
Healing Spree is a tongue-in-cheek hospital simulator featuring co-op for up to 4 players. Play as doctors on call to diagnose, help, and treat as many patients as humanly possible while maintaining your sanity AND friendships!
Also in Co-op · Funny, Colorful, Chaotic
51% of 83 Steam reviews are positive$14.99
HALF DEAD 2
A maze of cube rooms packed with deadly traps, where your shoes are your only tool for finding out which door kills you. Play solo, team up in co-op, or grab a weapon and hunt the other players. Every run is a new layout, and every wrong step is your last.
Also in Co-op · Funny, Chaotic, Fast-paced
84% of 1,852 Steam reviews are positive$4.99
Human Fall Flat
You are Bob, a wobbly human with no bones to speak of, falling through floating dreams. Grab, climb, haul boxes and break things solo or with up to 8 friends, where every smart plan usually ends with everyone in a pile on the floor.
Also in Co-op · Funny, Colorful, Chaotic
94% of 175,821 Steam reviews are positivePlayers online now: 2,640$19.99
BattleBlock Theater®
Play solo, grab a friend on the couch or online, and laugh at a narrator who never lets a serious moment stay serious.
Also in Co-op · Funny, Colorful, Chaotic
97% of 55,881 Steam reviews are positivePlayers online now: 109$14.99
Super Bunny Man
A physics platformer about a guy in a rabbit costume who rolls, jumps and grabs his way through wormholes, spikes and boulders. Play 50 levels solo or with friends, hunt hidden carrots, race the clock, then kick each other off cliffs in party mode. Wobbly, fast and very funny.
Also in Co-op · Funny, Colorful, Chaotic
85% of 10,309 Steam reviews are positivePlayers online now: 128$14.99
Invokyr
A cursed 1970s board game has trapped you and five friends in a groaning house, and the only way out is to play. You roll, something hunts you, and you scramble back to the board to roll again. Funny, tense, and built for a full group night.
Also in Co-op · Funny, Chaotic, Surreal
93% of 1,450 Steam reviews are positivePlayers online now: 1,143$12.99

Cheaper than S.E.M.I. – Side Effects May Include...

SIDE EFFECTS

Swallow, survive, and hope the box is kinder to you than to everyone else at the table.

$4.99

SOS OPS!

Team up as clumsy emergency responders and rescue a colorful city with wobbly physics, one laughing disaster at a time.

$0.49

Climb The Backrooms

Climb the Backrooms by throwing, stacking and outsmarting your way through physics puzzles, alone or with up to four players.

$4.99

HALF DEAD 2

Test trap-filled cube rooms with thrown shoes, climb floor by floor, and survive alone, in co-op or against up to 16 players.

$4.99

Split Brain

Share the same body with a friend in Split Brain. One of you controls, the other one sees, but the decisions are made together!

$5.99

Inside the Backrooms

Solve shifting puzzles and sneak past six entities in endless backrooms, scarier with friends along.

$6.99

Final Exam

Jump into the frenzied action and the whacky humor of a pure 2.5D side-scroller!

$4.99

Adventures of Shuggy

Shuggy has just inherited a castle full of goblins, ghouls, zombies, and robots.

$4.99

Chained Together

Climb a surreal vertical world while chained to your friends, where every jump is shared and every slip costs the whole group.

$4.99

Stuck Together

A co-op climbing game about two stuck-together toys on an escape mission from their evil owner.

$5.39

We Escaped a Twisted Game

A two-player co-op horror escape. Trapped in a haunted manor, you’ll need to solve puzzles, work together, and trust each other to make it out alive.

$4.99

Half Dead

Trapped in a deadly TV show, you search a maze of rooms for the exit while your friends test the doors with thrown shoes.

$1.99

Hidden gems like S.E.M.I. – Side Effects May Include...

Invokyr

Roll the dice, survive whatever the house sends, and play your way out of a cursed board game together.

$12.99

Mama's Sleeping Angels

Scavenge cursed objects through shifting dreamworlds with up to three friends, sneaking past what sleeps and shooting when it wakes.

$9.99

We Escaped a Twisted Game

A two-player co-op horror escape. Trapped in a haunted manor, you’ll need to solve puzzles, work together, and trust each other to make it out alive.

$4.99

the cabin game

Play cards to reshape the haunted cabin, uncover clues before time runs out, and choose who walks out alive.

$11.99

Flipping is Hard

Flippy is a smartphone with no legs, and the only way to move is by flipping.

$14.99

Paranoia Place: Escape Together

Team up with up to three friends to solve puzzles, hunt down randomly hidden items and survive a demon that grows faster the longer you stall.

$7.99

SIDE EFFECTS

Swallow, survive, and hope the box is kinder to you than to everyone else at the table.

$4.99

Split Brain

Share the same body with a friend in Split Brain. One of you controls, the other one sees, but the decisions are made together!

$5.99

Stuck Together

A co-op climbing game about two stuck-together toys on an escape mission from their evil owner.

$5.39

KLETKA

Ride a hungry lift with up to five friends, feed it fuel and flesh, and loot as deep into the Gigastructure as you dare.

$9.99

Climb The Backrooms

Climb the Backrooms by throwing, stacking and outsmarting your way through physics puzzles, alone or with up to four players.

$4.99

KarmaZoo

Share the love and die trying! KarmaZoo is a joyful, altruistic, cooperative platformer where up to 10 random players help each other with the…

$9.99

Newest games like S.E.M.I. – Side Effects May Include...