Games like Isolation

Hooked on the dark and story-driven side of Isolation? These games offer a similar pull for your backlog.

Pestis
A young Plague Doctor, only to learn that the Academy sent to a small village, which, like the whole country is gripped by plague
Dark, Story-driven, Atmospheric
76% of 88 Steam reviews are positive$24.99
Plague Inc: Evolved
You are Patient Zero's pathogen, and your job is to end human history. Plague Inc: Evolved is a tense strategy sim about spreading, mutating, and outsmarting cure labs, with 10 disease types, 23 scenarios, and endless custom plagues to try next.
Dark, Tense
94% of 59,897 Steam reviews are positivePlayers online now: 1,056$2.99
Mask of the Plague Doctor
Stop a deadly plague in a medieval fantasy tale of swords and surgery! Unearth medical knowledge, prevent the town’s purge, or plot your own escape.
Dark, Story-driven, Mysterious
85% of 62 Steam reviews are positive$7.99
Plague M.D.
Plague M.D. is a medieval medicine simulator. Become a quack doctor stuck in a backwater village in the 16th century.
Dark, Story-driven
74% of 135 Steam reviews are positive$5.99
The Book of Plagues
The city is drowning in Plague. Panic, hunger, and fear are tearing it apart. You are the last one who can change its fate: heal it, hold it back from collapse… or drive it to ruin with your own hands!
Dark, Story-driven, Atmospheric
95% of 19 Steam reviews are positive$0.69
Plagueworld
Adveture game based on medieval times, where you take the role of a hero that needs to fight and destroy the plague that invaded world.
Dark, Story-driven, Mysterious
58% of 66 Steam reviews are positiveFree
Isolania
A plague called "The Sadness" has devastated civilization. A mysterious society rose from the ashes, deciding the only way to protect its citizens is to confine them in cells. There are 3 Edicts governing this new civilization: Stay in your cell. Watch television. Never talk about the outside.
Dark, Story-driven, Mysterious
71% of 14 Steam reviews are positive$4.99
Dr. Plague
In a world ravaged by plague, a lone plague doctor embarks on a journey to stop both the disease and a sinister order of knights controlling it. Dr. Plague is a stealth-adventure game that combines puzzle-solving, platforming, and ambient soundtracks.
Dark, Story-driven, Mysterious
89% of 28 Steam reviews are positive$5.99
The Plague Doctor of Wippra
The plague spreads agony and fear in the small town of Wippra. As a plague doctor, you bring healing and relief wherever you can. But ignorance, superstition, and religious zeal make for a deadly threat in this retro medieval medical adventure!
Dark, Story-driven, Mysterious
88% of 367 Steam reviews are positive$7.99
Pathologic 2
A plague is eating a strange town on the steppe, and you have 12 days to do something about it. Pathologic 2 is a hard, story-driven survival RPG about running out of time: treat the sick, trade with children, autopsy bodies, and decide who deserves your last loaf of bread. You will not save everyone. That is the point.
Dark, Story-driven, Mysterious
92% of 9,645 Steam reviews are positivePlayers online now: 102$34.99
Self-Isolation
This game is a simulation of self-isolation. You need to support your family, not to lose your job and finally not to go crazy.
Dark, Story-driven, Mysterious
85% of 418 Steam reviews are positive$4.99
A Plague Tale: Innocence
A Plague Tale: Innocence follows Amicia and her little brother Hugo through 14th-century France while the Black Death spreads and the Inquisition hunts them. A dark, emotional story of two children surviving swarms of rats, told with striking visuals and a haunting soundtrack.
Dark, Story-driven, Mysterious
93% of 64,507 Steam reviews are positivePlayers online now: 683$3.99

Hidden gems like Isolation

Mycopsychosys: Remastered

🚨 Emergency Alert 🚨 New security protocols have been activated. Remain indoors. Do not open your doors under any circumstance. Isolation is safety.

$4.99

Pathologic 3

Diagnose the dying, rule a plague town by decree, and bend time itself to fix what went wrong.

$34.99

The Plague Doctor of Wippra

The plague spreads agony and fear in the small town of Wippra. As a plague doctor, you bring healing and relief wherever you can.

$7.99

Quarantine Zone: The Last Check

Scan the desperate, weigh each risk and hold the line at a checkpoint where one mistake lets the plague in.

$19.99

Self-Isolation

This game is a simulation of self-isolation. You need to support your family, not to lose your job and finally not to go crazy.

$4.99

Infection Free Zone

Build a survivor colony anywhere on the map, scavenge by day and fight off the infected when night falls.

$24.99

A Plague Tale: Requiem

Amicia and her little brother Hugo flee south, hoping to outrun the curse in his blood and the tide of rats that follows it.

$14.99

Bad Dream: Fever

Point & click through a plague-stricken city, solving strange riddles while a masked girl guides you over the walkie-talkie.

Free

Pathologic 2

A plague is eating a strange town on the steppe, and you have 12 days to do something about it.

$34.99

Plague M.D.

Plague M.D. is a medieval medicine simulator. Become a quack doctor stuck in a backwater village in the 16th century.

$5.99

A Plague Tale: Innocence

Guide Amicia and Hugo through a grim, cinematic stealth journey where hiding from rats and soldiers is the only way to stay alive.

$3.99

Pathologic Classic HD

Survive twelve days in a plague-stricken town, balancing resource management, desperate negotiations, and medical care.

$12.99

Newest games like Isolation

Mycopsychosys: Project Jupiter

Explore, investigate, and survive this new infection. Collect clues, meet and interact with people, and bond with the main cast.

$5.99

After Inc: Revival

Decades after the Necroa Virus, survivors climb out of their bunkers into a green, broken Britain.

$10.79

Symptoms of Infection

Examine and test patients for common and novel infections using sophisticated medical instrumentation. Isolate and treat infected patients.

$6.99

Devil of the Plague

A 1–4 player co-op horror game. Cleanse cursed lands, perform forbidden rituals, and survive a spreading plague. Fear is not scripted.

$9.99

Isolation Simulator

Have you ever dream to sit in your isolated room and contemplate your broken mind? Yeah... This game won't help you cure it.

$4.99

Extinction Day

You are the end of the world. Seed plagues, storms, volcanoes and wars across a 3D globe, feed the destruction back into upgrades, and stack…

$14.99

The Book of Plagues

The city is drowning in Plague. Panic, hunger, and fear are tearing it apart.

$0.69

Quarantine Zone: The Last Check

Scan the desperate, weigh each risk and hold the line at a checkpoint where one mistake lets the plague in.

$19.99

Pathologic 3

Diagnose the dying, rule a plague town by decree, and bend time itself to fix what went wrong.

$34.99

Get In Get Out

Guard the quarantine gate of District Eight. Question survivors, check for signs of infection, and decide who gets in, who gets out, and who might…

$3.99

CURE - A Hospital Simulator

Triage the infected, keep the budget alive and run an emergency room with friends while the apocalypse waits outside.

$6.69

Mycopsychosys: Remastered

🚨 Emergency Alert 🚨 New security protocols have been activated. Remain indoors. Do not open your doors under any circumstance. Isolation is safety.

$4.99